1. MATERIALS AND METHODS: In micronucleus test, glyphosate was given twice via intragastric administration to different groups of mice at different concentrations(2320 mg/kg, 1160 mg/kg, 580 mg/kg) at a 24-hour interval. Mice were killed 6 hours after last treatment to determine the micronucleus rates of polychromatic erythrocytes in the bone marrow. For sperm shape abnormality test, all mice were treated with glyphosate for 5 consecutive days at concentrations of 1160 mg/kg, 290 mg/kg and 580 mg/kg. In the 1st and 4th week after the first treatment, half of mice were killed each time to regularly examine the sperm aberration rates, to count the total number of sperm, to weigh the testis and the epididymis, and to observe the change of organ coefficient.
材料与方法：采用骨髓微核试验：以不同剂量(2 320、1 160、580 mg/kg)的草甘膦分2次经口灌胃染毒小鼠，每次间隔24 h ，于末次染毒后6 h 处死小鼠，检测骨髓嗜多染红细胞微核率；雄性小鼠精子畸形试验：设1 160、580、290 mg/kg 的3个草甘膦剂量组，经口灌胃连续染毒5 d ，于首次染毒后第1、4周分2批处死动物，常规观察精子畸形率、精子数和睾丸、附睾重量及其脏器系数的变化。
2. \u0064\u0061\u006E\u0063\u0069\u002E\u0039\u0031\u0031\u0063\u0068\u0061\u002E\u0063\u006F\u006D
2. Methods:analysis of 21 cases of myocardial infarction after trauma on their pathogenesis, type of trauma, clinical manifestation, classification, diagnosis and prognosis of cardial infarction. discussion of its pathogenesis and other related questions. results: most of the 21 patients got onset of myocardial infarction 1~2 hours after trauma. the shortest interval between trauma and onset of myocardial infarction was half an hour while the longest was 24 hours. some of the patients showed atypical symptoms because of interference of trauma symptoms, but routine ecg and enzyme assay can give definite diagnosis. after active treatment, most of the patients got rehabilitation discharge and eusemia except two patients died of senility and serious illness respectively. conclusions: traumatic myocardial infarction is common among trauma patients. if doctors pay enough attention and give definite diagnosis in time, the patient can get fine prognosis. as the number of the cases was not enough, we did not analyze the relationship between different type of trauma and myocardial infarction and the relationship between different part of myocardial infarction and trauma. but we can tell that the disease is caused by multiple factors other than single factor.
对21例外伤病人伤后心肌梗死的发病情况、外伤类型、以及心梗的临床表现、心梗的类型、诊断及转归进行了分析，并对其发病机制和其他相关问题进行了讨论。结果：21例病人外伤后至心梗的发病时间最短者0.5小时，最长者24小时，多数在伤后1~2小时发病，由于外伤症状的掩盖，有的病人症状常不典型，但常规的心电图及酶学等检查均能明确诊断。经积极的治疗，1例由于病人高龄、1例入院时情况危重而死亡外，其余病人均康复出院，预后良好。结论：外伤性心肌梗死在外伤的病人中较常见，接诊医生提高警惕能及时给予明确的诊断，预后良好。不同类型的外伤与心肌梗死的关系、以及不同部位心梗与外伤的关系，由于病例较少，未能进行分析。其发病机制不是单一原因，而是多因素而致。外伤；心肌梗死；分析
3. Results:Losartan had a total effective rate of 87.5% and exerted its antihypertensive effect throughout 24 hour dose-interval without alternation of heart rate and blood pressure circadian(p＜0.05、0.01).Besides, T/P ratio of systolic pressure and diastolic pressure were larger than 50%.
结果：氯沙坦治疗6周，降压总有效率为87.5%；24小时各时点血压均较治疗前显著下降(P＜0.05、P＜0.01)，不伴有心率及血压昼夜节律的改变；降低收缩压和舒张压的谷/峰值分别为52.9%和63.6%。
4. Results:Losartan had a total effective rate of 87.5%and exerted its antihypertensive effect throughout 24 hour dose-interval without alternation of heart rate and blood pressure circadianp Conclusion:Losartan 50～100 mg once daily can effectively control the blood pressure throughout 24 hour in mild to moderate essential hypertension and it is well tolerated.
结果：氯沙坦治疗6周，降压总有效率为87.5%：24小时各时点血压均较治疗前显著下降P 结论：氯沙坦50～100 mg，每日1次能平稳、有效地控制EH患者24小时血压，且患者总体耐受良好。